Unité des maladies neuromusculaires

Responsable de l'Unité des maladies neuromusculaires
Dre Agustina LASCANO
Médecin adjointe agrégée
neuromusculaire-secretariat@hug.ch

L'unité mène les travaux de recherche dans les domaines suivants :

Myasthénie gravis

Corrélation entre la fatigue et le fonctionnement diaphragmatique (respiration) en collaboration avec le Service de pneumologie des HUG
Sécurité et efficacité du traitement rituximab en collaboration avec le Service de neurologie du CHUV (Dre Marie Théaudin)

Douleur neuropathique

Evaluation objective de la douleur neuropathique dans la sclérose en plaques via des potentiels évoqués laser
Neuropathie des petites fibres post-COVID 19 en collaboration avec la consultation long-COVID

Neuropathie inflammatoire

Participation au registre international de l’étude sur la polyradiculonévrite inflammatoire chronique (PIDC ; INCbase)

Maladie de motoneurone

Recherche sur les biomarqueurs électrophysiologiques dans la sclérose latérale amyotrophique (SLA) en collaboration avec le Centre hospitalier universitaire de Clermont-Ferrand
Etude longitudinale sur les troubles cognitifs et de la parole chez les patients atteints d’une maladie SLA (en collaboration avec l’unité de neuropsychologie)
Raccourcir le délai diagnostique dans les maladies du motoneurone et d’autres maladies neurodégénératives avec des nouvelles méthodes électrophysiologiques.

Notre équipe participe à des études multicentriques en collaboration avec des centres d’excellence internationaux et nationaux.

Futur projets

Participation à l’élaboration des registres suisses pour les maladies du motoneurone, myasthénie et polyradiculonévrite inflammatoire demyélinisante chronique (PIDC)
Intérêt de l’ultrason des nerfs et des muscles dans les maladies du système nerveux périphérique.

Publications

2023
2022
2021
2020
2019
2018
2017
2016

Ripellino P, Lascano AM, Scheidegger O, Schilg-Hafer L, Schreiner B, Tsouni P, Vicino A, Peyer AK, Humm AM, Décard BF, Pianezzi E, Zezza G, Sparasci D, Hundsberger T, Dietmann A, Jung H, Kuntzer T, Wilder-Smith E, Martinetti-Lucchini G, Petrini O, Fontana S, Gowland P, Niederhauser C, Gobbi C. Neuropathies related to hepatitis E virus infection: A prospective, matched case-control study. Eur J Neurol. 2024 Jan;31(1):e16030. doi: 10.1111/ene.16030. Epub 2023 Aug 25. PMID: 37548584.
Iannotti GR, Nadin I, Ivanova V, Tourdot Q, Lascano AM, Momjian S, Schaller KL, Lovblad KO, Grouiller F. Specificity of Quantitative Functional Brain Mapping with Arterial Spin-Labeling for Preoperative Assessment. AJNR Am J Neuroradiol. 2023 Nov;44(11):1302-1308. doi: 10.3174/ajnr.A8006. Epub 2023 Oct 19. PMID: 37857448; PMCID: PMC10631521.
Gautier Breville,Egle Sukockiene,Maria Isabel Vargas &Agustina M. Lascano Emerging biomarkers to predict clinical outcomes in Guillain–Barré syndrome, Taylor&Francis online, 2023 April18.

Lucas S, Lalive PH, Lascano AM. Paroxysmal painful tonic spasms in neuromyelitis optica spectrum disorder. eNeurologicalSci. 2023 Jan 13;30:100443. doi: 10.1016/j.ensci.2023.100443. PMID: 36698772; PMCID: PMC9868373.
Truffert A, Sukockienė E, Desmaison A, Ališauskienė M, Iancu Ferfoglia R, Guy N. Combined tendon reflex and motor evoked potential recordings in amyotrophic lateral sclerosis. Clin Neurophysiol. 2023 Jan 23;147:88-98. doi: 10.1016/j.clinph.2022.12.013. Epub ahead of print. PMID: 36753809.

Vicino A, Fayolle D, Ochsner F, Echaniz-Laguna A, Magy L, Hübers A, Théaudin M. Maladies musculaires de l’adulte : quand évoquer le diagnostic ? [Muscle disease in the adults: when to suspect it?]. Rev Med Suisse. 2022 Apr 27;18(779):799-802. French. doi: 10.53738/REVMED.2022.18.779.799. PMID:35481504.
Théaudin M, Ochsner F, Adam C, Echaniz-Laguna A, Magy L, Fayolle D, Vicino A, Hübers A, Pereon Y. Diagnostiquer une neuropathie des petites fibres [Small fiber neuropathy diagnosis]. Rev Med Suisse. 2022 Apr 27;18(779):803-807. French. doi: 10.53738/REVMED.2022.18.779.803. PMID: 35481505.
Sukockienė E, Assal F, Hübers A. Are nerve conduction studies altered in functional neurological disorders? Clin Neurophysiol Pract. 2022 Jun 2;7:166-168. doi: 10.1016/j.cnp.2022.05.003. PMID: 35756575; PMCID: PMC9214718.
Ochsner F, Kuntzer T, Vicino A, Hübers A, Fayolle D, Echaniz-Laguna A, Magy L, Théaudin M, Tatu L. Douleurs et faiblesse de l’épaule neurologique : attitudes pratiques [Neurological shoulder pain and weakness : practical attitudes]. Rev Med Suisse. 2022 Apr 27;18(779):794-798. French. doi:10.53738/REVMED.2022.18.779.794. PMID: 35481503.
Müller HP, Nagel AM, Keidel F, Wunderlich A, Hübers A, Gast LV, Ludolph AC, Beer M, Kassubek J. Relaxation-weighted <sup>23</sup>Na magnetic resonance imaging maps regional patterns of abnormal sodium concentrations in amyotrophic lateral sclerosis. Ther Adv Chronic Dis. 2022 Jul 8;13:20406223221109480. doi:10.1177/20406223221109480. PMID: 35837670; PMCID: PMC9274400.
Magy L, Echaniz-Laguna A, Fayolle D, Hübers A, Ochsner F, Vicino A, Théaudin M. Qu’avons-nous compris en 20 ans sur la polyradiculoneuropathie inflammatoire démyélinisante chronique ? [What have we learned about chronic inflammatory demyelinating polyradiculoneuropathyin the last twenty years ?]. Rev Med Suisse. 2022 Apr 27;18(779):808-812. French. doi: 10.53738/REVMED.2022.18.779.808. PMID:35481506.
Hübers A, Fayolle D, Ochsner F, Echaniz-Laguna A, Magy L, Vicino A, Théaudin M. Crampes et fasciculations : est-ce une sclérose latérale amyotrophique ? [Cramps and fasciculations: is it amyotrophic lateral sclerosis?]. Rev Med Suisse. 2022 Apr 27;18(779):790-793. French. Doi: 10.53738/REVMED.2022.18.779.790. PMID: 35481502.
Fayolle D, Théaudin M, Ochsner F, Echaniz-Laguna A, Magy L, Vicino A, Hübers A. Crampes musculaires [Muscle cramps]. Rev Med Suisse. 2022 Apr 27;18(779):785-788. French. doi: 10.53738/REVMED.2022.18.779.785. PMID: 35481501.
Echaniz-Laguna A, Magy L, Vicino A, Fayolle D, Hübers A, Ochsner F, Théaudin M. Traiter les neuropathies héréditaires : un rêve qui devient réalité ? [Treating hereditary neuropathies : a dream come true?]. Rev Med Suisse. 2022 Apr 27;18(779):813-816. French. doi: 10.53738/REVMED.2022.18.779.813. PMID: 35481507.
Hardmeier M, Schlaeger R, Lascano AM, Toffolet L, Schindler C, Gobbi C, Lalive P, Kuhle J, Kappos L, Fuhr P. Prognostic biomarkers in primary progressive multiple sclerosis: Validating and scrutinizing multimodal evoked potentials. Clin Neurophysiol. 2022 May;137:152-158. doi: 10.1016/j.clinph.2022.02.019. Epub 2022 Mar 7. PMID: 35316624.

Guillain-Barré Syndrome After SARS-CoV-2 Infection in an International Prospective Cohort Study
Linda W. G. Luijten; Sonja E. Leonhard; Annemiek A. van der Eijk; Alex Y. Doets; Luise Appeltshauser; Samuel Arends; Shahram Attarian; Luana Benedetti; Chiara Briani; Carlos Casasnovas; Francesca Castellani; Efthimios Dardiotis; Andoni Echaniz-Laguna; Marcel P. J. Garssen; Thomas Harbo; Ruth Huizinga; Andrea M. Humm; Korné Jellema; Anneke J. van der Kooi; Krista Kuitwaard; Thierry Kuntzer; Susumu Kusunoki; Agustina M. Lascano; Eugenia Martinez-Hernandez; Simon Rinaldi; Johnny P. A. Samijn; Olivier Scheidegger; Pinelopi Tsouni; Alex Vicino; Leo H. Visser; Christa Walgaard; Yuzhong Wang; Paul W. Wirtz; Paolo Ripellino; Bart C. Jacobs. Brain. 2021;144(11):3392-3404.

Interleukin 8, a Biomarker to Differentiate Guillain-Barré Syndrome From CIDP.
Breville G, Lascano AM, Roux-Lombard P, Vuilleumier N, Lalive PH. Neurol Neuroimmunol Neuroinflamm. 2021 Jun 17;8(5):e1031. doi: 10.1212/NXI.0000000000001031.

Small fiber neuropathy in systemic autoimmune diseases. Breville G, Fayolle D, Lascano AM, Lalive P, Seebach JD. Rev Med Suisse. 2021 Apr 7;17(733):697-701.
Expert recommendation from the Swiss Amyloidosis Network (SAN) for systemic AL-amyloidosis.
Schwotzer R, Flammer AJ, Gerull S, Pabst T, Arosio P, Averaimo M, Bacher VU, Bode P, Cavalli A, Concoluci A, Dirnhofer S, Djerbi N, Dobner SW, Fehr T, Garofalo M, Gaspert A, Heimgartner R, Hübers A, Jung HH, Kessler C, Knöpfel R, Laptseva N, Manka R, Mazzucchelli L, Meyer M, Mihaylova V, Monney P, Mylonas A, Nkoulou R, Pazhenkottil A, Pfister O, Rüfer A, Schmidt A, Seeger H, Stämpfli SF, Stirnimann G, Suter T, Théaudin M, Treglia G, Tzankov A, Vetter F, Zweier M, Gerber B.
Swiss Med Wkly. 2020 Dec 5;150:w20364. doi: 10.4414/smw.2020.20364. eCollection 2020 Nov 30.
PMID: 33277911
Preface: promoting research in PLS: current knowledge and future challenges.
Mitsumoto H, Turner MR; all Delegates of the PLS Conference, Ajroud-Driss S, Andres P, Andrews J, Gomez EA, Atehortua JMS, Babu S, Barohn R, Bede P, Benatar M, Chew S, Conwit R, Corcia P, Cudkowicz M, Davis F, Carvalho M, Drory V, Elman L, Factor-Litvak P, Fernandes JAM, Ferrey D, Finegan E, Fink J, Floeter MK, Fournier C, Genge A, Govindarajan R, Granit V, Haase G, Hardiman O, Harms M, Hayat G, Heiman-Patterson T, Hill B, Hübers A, Huey E, Jawdat O, Kano O, Kau K, Kiernan M, Kisanuki Y, Kurent J, Kwan J, Lange D, Ludolph A, Mackenzie I, Manfredi G, Marren D, Morita M, Murphy J, Nations S, Oskarsson B, Paganoni S, Pellerin D, Ravits J, Rezania K, Rouleau G, Scelsa S, Siddique T, Siddique N, Silani V, Simmons Z, Statland J, Traynor B, Blitterswijk MV, Berg LVD, Walk D, Warden D, Wymer J.
Amyotroph Lateral Scler Frontotemporal Degener. 2020 Nov;21(sup1):1-2. doi: 10.1080/21678421.2020.1840795.
PMID: 33602018 No abstract available.
Altered perivascular fibroblast activity precedes ALS disease onset.
Månberg A, Skene N, Sanders F, Trusohamn M, Remnestål J, Szczepińska A, Aksoylu IS, Lönnerberg P, Ebarasi L, Wouters S, Lehmann M, Olofsson J, von Gohren Antequera I, Domaniku A, De Schaepdryver M, De Vocht J, Poesen K, Uhlén M, Anink J, Mijnsbergen C, Vergunst-Bosch H, Hübers A, Kläppe U, Rodriguez-Vieitez E, Gilthorpe JD, Hedlund E, Harris RA, Aronica E, Van Damme P, Ludolph A, Veldink J, Ingre C, Nilsson P, Lewandowski SA.
Nat Med. 2021 Apr;27(4):640-646. doi: 10.1038/s41591-021-01295-9. Epub 2021 Apr 15.
PMID: 33859435
Lascano AM, Lalive PH. Update in immunosuppressive therapy of myasthenia gravis. Autoimmun Rev, 2021 Jan;20(1):102712.

Hübers A, Lascano AM, Lalive PH. Management of patients with generalised myasthenia gravis and COVID-19: four case reports. J Neurol Neurosurg Psychiatry 2020; 91:1124-1125.

Coen M, Jeanson G, Culebras Almeida LA, Hübers A, Stierlin F, Najjar I, Ongaro M, Moulin K, Makrygianni M, Leemann B, Kronig I, Bertrand J, Reny JL, Schibler M, Serratrice J. Guillain-Barré syndrome as a complication of SARS- CoV-2 infection. Brain Behav Immun. 2020 Jul;87:111-112.

Sukockiené E, Magistris MR, Iancu Ferfoglia R, Lascano AM, Truffert A. Impaired conduction of Ia sensory fibers in multifocal motor neuropathy: an electrophysiological demonstration. Clin Neurophysiol Pract 2020; 5:152-156.

Hübers A, Böckler B, Abaei A, Rasche V, Lulé D, Ercan E, Doorenweerd N, Müller HP, Dreyhaupt J, Kammer T, Ludolph AC, Ronen I, Kassubek J. Functional and structural impairment of transcallosal motor fibres in ALS: a study using transcranial magnetic stimulation, diffusion tensor imaging, and diffusion weighted spectroscopy. Brain Imaging Behav. 2020 Apr 18.

Lascano AM, Epiney JB, Coen M, Serratrice J, Bernard-Valnet R, Lalive PH, Kuntzer T, Hübers A. SARS-CoV-2 and Guillain-Barré syndrome: AIDP variant with favorable outcome. EJN 2020 (Epub).

Huttner A, Eperon G, Lascano AM, Roth S, Schwob JM, Siegrist CA, Lalive PH. Risk of MS relapse after yellow fever vaccination: a self-controlled case series. Neurol Neuroimmunol Neuroinflamm 2020; 7:e726.

Jannelli G, Baticam NS, Tizi K, Truffert A, Lascano AM, Tessitore E. Symptomatic tandem spinal stenosis: a clinical, diagnostic and surgical challenge. Neurosurg Rev 2020; 43:1289-1295.

Huttner A, Lascano AM, Eperon G, Roth S, Schwob JM, Siegrist CA, Lalive PH. The risk of multiple sclerosis relapse after rabies vaccination: a self-controlled case series (Soumis et en révision).

Turner MR, Barohn RJ, Corcia P, Fink JK, Harms MB, Kiernan MC, Ravits J, Silani V, Simmons Z, Statland J, van den Berg LH; Delegates of the 2nd International PLS Conference, Mitsumoto H. Primary lateral sclerosis: consensus diagnostic criteria. J Neurol Neurosurg Psychiatry. 2020 Apr;91(4):373-377.

Tazelaar GHP, Dekker AM, van Vugt JJFA, van der Spek RA, Westeneng HJ, Kool LJBG, Kenna KP, van Rheenen W, Pulit SL, McLaughlin RL, Sproviero W, Iacoangeli A, Hübers A, Brenner D, Morrison KE, Shaw PJ, Shaw CE, Panadés MP, Mora Pardina JS, Glass JD, Hardiman O, Al-Chalabi A, van Damme P, Robberecht W, Landers JE, Ludolph AC, Weishaupt JH, van den Berg LH, Veldink JH, van Es MA; Project MinE ALS Sequencing Consortium. Association of NIPA1 repeat expansions with amyotrophic lateral sclerosis in a large international cohort. Neurobiol Aging. 2019 Feb;74:234.e9-234.

Breville G, Lascano AM, Roux-Lombard P, Vuilleumier N, Lalive P. IL-8 as a potential biomarker in Guillain-Barre syndrome. Eur Cytokine Netw 2019 ; 30 :130-134.

Naumann M, Peikert K, Günther R, van der Kooi AJ, Aronica E, Hübers A, Danel V, Corcia P, Pan-Montojo F, Cirak S, Haliloglu G, Ludolph AC, Goswami A, Andersen PM, Prudlo J, Wegner F, Van Damme P, Weishaupt JH, Hermann A. Phenotypes and malignancy risk of different FUS mutations in genetic amyotrophic lateral sclerosis. Ann Clin Transl Neurol. 2019 Dec;6(12):2384-2394.

Breville G, Lascano AM, Merkler D, Roth S, Lalive PH. Fulminant multifocal relapse in a fingolimod-treated multiple sclerosis patient. Mult Scler Relat Disord 2019 (Epub).

Brenner D, Rosenbohm A, Yilmaz R, Müller K, Grehl T, Petri S, Meyer T, Grosskreutz J, Weydt P, Ruf W, Neuwirth C, Weber M, Pinto S, Claeys KG, Schrank B, Jordan B, Knehr A, Günther K, Hübers A, Zeller D, Kubisch C, Jablonka S, Sendtner M, Klopstock T, de Carvalho M, Sperfeld A, Borck G, Volk AE, Dorst J, Weis J, Otto M, Schuster J, Del Tredici K, Braak H, Danzer KM, Freischmidt A, Meitinger T, Ludolph AC, Andersen PM, Weishaupt JH; German ALS network MND-NET. Reply: Adult-onset distal spinal muscular atrophy: a new phenotype associated with KIF5A mutations. Brain. 2019 Dec 1;142(12):e67.

De Stefano P, Lascano AM, Schibler M, Fistori A, Lalive P, Gschwind M. Pachymeningitis associated to extrapulmonary tuberculosis and secondary antiphospholipid antibodies syndrome. Mult Scler Relat Disord 2019; 29:83-85.

Picchiarelli G, Demestre M, Zuko A, Been M, Higelin J, Dieterlé S, Goy MA, Mallik M, Sellier C, Scekic-Zahirovic J, Zhang L, Rosenbohm A, Sijlmans C, Aly A, Mersmann S, Sanjuan-Ruiz I, Hübers A, Messaddeq N, Wagner M, van Bakel N, Boutillier AL, Ludolph A, Lagier-Tourenne C, Boeckers TM, Dupuis L, Storkebaum E. FUS-mediated regulation of acetylcholine receptor transcription at neuromuscular junctions is compromised in amyotrophic lateral sclerosis. Nat Neurosci. 2019 Nov;22(11):1793-1805.

Lamartine Monteiro M, Lascano AM, Meunier Carus Vincent N, Seebach JD, Lalive P, Gschwind M. AQP4-positive longitudinal extensive transverse myelitis associated with Takayasu arteritis. J Neurol Sci 2019; 396:130-132.

Dorst J, Chen L, Rosenbohm A, Dreyhaupt J, Hübers A, Schuster J, Weishaupt JH, Kassubek J, Gess B, Meyer T, Weyen U, Hermann A, Winkler J, Grehl T, Hagenacker T, Lingor P, Koch JC, Sperfeld A, Petri S, Großkreutz J, Metelmann M, Wolf J, Winkler AS, Klopstock T, Boentert M, Johannesen S, Storch A, Schrank B, Zeller D, Liu XL, Tang L, Fan DS, Ludolph AC. Prognostic factors in ALS: a comparison between Germany and China. J Neurol. 2019 Jun;266(6):1516-1525.

Schibler M, Eperon G, Kenfak A, Lascano A, Vargas MI, Stahl JP. Diagnostic tool to tackle infectious causes of encephalitis and meningoencephalitis in immunocompetent adults in Europe. Clin Microbiol Infect 2019; 25:408-414.

Lascano AM, Vargas MI, Lalive P. Diagnostic tools for immune causes of encephalitis. Clin Microbiol Infect 2019; 25:431-436.

Hübers A, Huppertz HJ, Wortmann SB, Kassubek J. Mutation of the <i>WARS2</i> Gene as the Cause of a Severe Hyperkinetic Movement Disorder. Mov Disord Clin Pract. 2019 Nov 7;7(1):88-90.

2018

Müller K, Brenner D, Weydt P, Meyer T, Grehl T, Petri S, Grosskreutz J, Schuster J, Volk AE, Borck G, Kubisch C, Klopstock T, Zeller D, Jablonka S, Sendtner M, Klebe S, Knehr A, Günther K, Weis J, Claeys KG, Schrank B, Sperfeld AD, Hübers A, Otto M, Dorst J, Meitinger T, Strom TM, Andersen PM, Ludolph AC, Weishaupt JH; German ALS network MND-NET. Comprehensive analysis of the mutation spectrum in 301 German ALS families. J Neurol Neurosurg Psychiatry. 2018 Aug;89(8):817-827.

De Stefano P, Chizzolini C, Lalive PH, Lascano AM. Limbic encephalitis complicating systemic sclerosis. Mult. Scler Rel. Disord. 2018; 24: 142-144.

Marroquin N, Stranz S, Müller K, Wieland T, Ruf WP, Brockmann SJ, Danzer KM, Borck G, Hübers A, Weydt P, Meitinger T, Strom TM, Rosenbohm A, Ludolph AC, Weishaupt JH. Screening for CHCHD10 mutations in a large cohort of sporadic ALS patients: no evidence for pathogenicity of the p.P34S variant. Brain. 2016 Feb;139(Pt 2):e8.

Abdelhak A, Hübers A, Böhm K, Ludolph AC, Kassubek J, Pinkhardt EH. In vivo assessment of retinal vessel pathology in amyotrophic lateral sclerosis. J Neurol. 2018 Apr;265(4):949-953. doi: 10.1007/s00415-018-8787-x. Epub 2018 Feb 20.

Hübers A, Thoma K, Schocke M, Fauser S, Ludolph AC, Kassubek J, Pinkhardt EH. Acute DWI Reductions In Patients After Single Epileptic Seizures – More Common Than Assumed. Front Neurol. 2018 Jul 25;9:550.

Brenner D, Yilmaz R, Müller K, Grehl T, Petri S, Meyer T, Grosskreutz J, Weydt P, Ruf W, Neuwirth C, Weber M, Pinto S, Claeys KG, Schrank B, Jordan B, Knehr A, Günther K, Hübers A, Zeller D, Kubisch C, Jablonka S, Sendtner M, Klopstock T, de Carvalho M, Sperfeld A, Borck G, Volk AE, Dorst J, Weis J, Otto M, Schuster J, Del Tredici K, Braak H, Danzer KM, Freischmidt A, Meitinger T, Strom TM, Ludolph AC, Andersen PM, Weishaupt JH; German ALS network MND-NET. Hot-spot KIF5A mutations cause familial ALS. Brain. 2018 Mar 1;141(3):688-697.

Gschwind M, Lascano AM, Gürkan K, Assal F. Self-injurious behavior unveiling a case of advanced primary progressive multiple sclerosis with a massive right temporal lesion. J Clin Neurol 2018; 14: 251-253.

Neuwirth C, Braun N, Claeys KG, Bucelli R, Fournier C, Bromberg M, Petri S, Goedee S, Lenglet T, Leppanen R, Canosa A, Goodman I, Al-Lozi M, Ohkubo T, Hübers A, Atassi N, Abrahao A, Funke A, Appelfeller M, Tümmler A, Finegan E, Glass JD, Babu S, Ladha SS, Kwast-Rabben O, Juntas-Morales R, Coffey A, Chaudhry V, Vu T, Saephanh C, Newhard C, Zakrzewski M, Rosier E, Hamel N, Raheja D, Raaijman J, Ferguson T, Weber M. Implementing Motor Unit Number Index (MUNIX) in a large clinical trial: Real world experience from 27 centres. Clin Neurophysiol. 2018 Aug;129(8):1756-1762.

Higelin J, Demestre M, Putz S, Delling JP, Jacob C, Lutz AK, Bausinger J, Huber AK, Klingenstein M, Barbi G, Speit G, Hubers A, Weishaupt JH, Hermann A, Liebau S, Ludolph AC, Boeckers TM. FUS Mislocalization and Vulnerability to DNA Damage in ALS Patients Derived hiPSCs and Aging Motoneurons. Front Cell Neurosci. 2016 Dec 26;10:290.

Fisch L, Lascano AM, Vernaz Hegi N, Girardin F, Kapina V, Heydrich L, Rutschmann O, Sarasin F, Vargas MI, Picard F, Vulliemoz S, Heritier AC, Seeck M. Early-specialized care after a first unprovoked epileptic seizure. J Neurol 2016; 263: 2386-2394.

Rosenbohm A, Müller HP, Hübers A, Ludolph AC, Kassubek J. Corticoefferent pathways in pure lower motor neuron disease: a diffusion tensor imaging study. J Neurol. 2016 Dec;263(12):2430-2437.

Hübers A, Hildebrandt V, Petri S, Kollewe K, Hermann A, Storch A, Hanisch F, Zierz S, Rosenbohm A, Ludolph AC, Dorst J. Clinical features and differential diagnosis of flail arm syndrome. J Neurol. 2016 Feb;263(2):390-395.

Tyrand R, Momjian S, Pollo C, Lysakowski C, Lascano AM, Vulliemoz S, Schaller K, Boex C. Continuous intraoperative monitoring of temporal lobe epilepsy surgery. Stereotac Funct Neurosurg 2016; 94: 404-412.

Hübers A, Ludolph AC, Rosenbohm A, Pinkhardt EH, Weishaupt JH, Dorst J. Amyotrophe Lateralsklerose. Eine Multisystemdegeneration [Amyotrophic lateral sclerosis. Multisystem degeneration]. Nervenarzt. 2016 Feb;87(2):179-88.

Lascano AM, Pernegger T, Vulliemoz S, Spinelli L, Garibotto V, C. Korff, Vargas MI, Michel CM, Seeck M. Yield of MRI, high-density source imaging (HD-ESI), SPECT and PET in epilepsy surgery candidates. Clin Neurophysiology 2016; 127: 5-7.

Hübers A, Müller HP, Dreyhaupt J, Böhm K, Lauda F, Tumani H, Kassubek J, Ludolph AC, Pinkhardt EH. Retinal involvement in amyotrophic lateral sclerosis: a study with optical coherence tomography and diffusion tensor imaging. J Neural Transm (Vienna). 2016 Mar;123(3):281-7.

Lascano AM, Korff C, Picard F. Seizures and epilepsies due to channelopathies and neurotransmitter receptor dysfunction: a parallel between genetic and immune aspects. Mol Syndromol 2016; 7:197-209.

Brenner D, Müller K, Wieland T, Weydt P, Böhm S, Lulé D, Hübers A, Neuwirth C, Weber M, Borck G, Wahlqvist M, Danzer KM, Volk AE, Meitinger T, Strom TM, Otto M, Kassubek J, Ludolph AC, Andersen PM, Weishaupt JH. NEK1 mutations in familial amyotrophic lateral sclerosis. Brain. 2016 May;139(Pt 5):e28.

Hübers A, Kassubek J, Grön G, Gorges M, Aho-Oezhan H, Keller J, Horn H, Neugebauer H, Uttner I, Lulé D, Ludolph AC. Pathological laughing and crying in amyotrophic lateral sclerosis is related to frontal cortex function. J Neurol. 2016 Sep;263(9):1788-95.

Wahl M, Lauterbach-Soon B, Hattingen E, Hübers A, Ziemann U. Callosal anatomical and effective connectivity between primary motor cortices predicts visually cued bimanual temporal coordination performance. Brain Struct Funct. 2016 Sep;221(7):3427-43.

Rennebaum F, Kassubek J, Pinkhardt E, Hübers A, Ludolph AC, Schocke M, Fauser S. Status epilepticus: Clinical characteristics and EEG patterns associated with and without MRI diffusion restriction in 69 patients. Epilepsy Res. 2016 Feb;120:55-64.